Dr. Yunfeng Chen, The Scripps Research Institute, USA Professor David Bark, Colorado State University, USA Dr. David Martínez-Martín, ETH Zürich, Switzerland Dr. Lining Arnold Ju, University of Sydney, Australia
Dr. Mingxing Ouyang, Changzhou University, China Dr. Peter Yingxiao Wang, University of California, San Diego, USA Dr. Kathy Shaoying Lu, University of California, San Diego, USA Dr. Jack Wei Chen, Zhejiang University, China
Dr. Xiaobo Gong, Shanghai Jiao Tong University, China Dr. Ming Dao, Massachusetts Institute of Technology, USA Dr. Ken-ichi Tsubota, Chiba University, Japan Dr. Chunyang Xiong, Peking University, China
#1: Mini-Symposium: 3D/4D Printing for Tissue Engineering
Dr. Lijie Grace Zhang, The George Washington University
Professor James D. Lee, The George Washington University
Summary: This symposium aims to bring together experts across the range of engineering science disciplines to discuss the state-of-the-art in development of 3D/4D printing techniques for various biomedical applications. As an emerging biomanufacturing technique, 3D printing offers great precision and control of the internal architecture and outer shape of a scaffold, allowing for close recapitulation of complicated structures found in biological tissue/organ. It has begun to show great promise in tissue engineering. The symposium will highlight challenges spanning from design of innovative printing systems and printable biomaterials, to fabrication, and to implantation. Computational and analytical challenges will be a special focus. Topics will include but not be limited to: • Computational simulation for 3D/4D printed materials and structures • Simulation of cell-material interaction or 3D tissue constructs • 3D/4D printed tissue and organ models • Advanced additive manufacture techniques • 3D/4D printing for tissue and organ regeneration • Design and applications of advanced printable biomaterials.
#2: Mini Symposium: Vulnerable Plaque Biomechanics and Clinical Applications
Professor Dalin Tang, Worcester Polytechnic Institute
Dr. Liang Wang, Southeast University
Professor Jacques Ohayon, University Savoie Mont-Blanc
Summary: This symposium aims to bring together experts across the range of engineering science disciplines to discuss the state-of-the-art in development of vulnerable plaque biomechanics and its clinical application. Atherosclerotic plaque development and rupture are closely associated the plaque mechanical conditions, including hemodynamics and structural mechanics. These mechanical conditions have the potential to improve the assessment the vulnerable plaque and forecasting adverse major cardiovascular events with integration of plaque morphology from multiple non-invasive or invasive imaging technologies. The symposium will highlight the experimental and computational techniques in the vulnerable plaque biomechanical research, and the influence of biomechanics in clinical patient-screening, diagnosis and intervention for atherosclerosis-related cardiovascular diseases.
Topics will include but not be limited to: • Computational simulation for plaque biomechanics; • Experimental investigation for plaque material properties and biomechanics; • Clinical Application for plaque biomechanics; • Image-based modeling and numerical technologies;
#3: Mini Symposium: Ventricle Modeling, Biomechanics and Clinical Application
Professor Dalin Tang, Worcester Polytechnic Institute
Professor Xueying Huang, Xiamen University
Summary: This symposium aims to bring experts together and provide a platform for exchange of ideas and disseminate the recent developments in Ventricle Modeling, Biomechanics and Clinical Application. The symposium will highlight challenges spanning from heart modeling (including ventricles and valve modeling) to dissect the mechanisms for cardiac dysfunction, cardiac hemodynamics, and cardiac valves. Computational, analytical challenges and clinical applications will be a special focus.
Topics will include but not be limited to: • Computational modeling for ventricles • Multi-scale of heart function • Modeling of heart valves • Cardiac tissue mechanics • Ventricular hemodynamics • Biomechanical Heart Modeling for Clinical Applications
#4: Mini Symposium:Inverse Problems In Soft Tissue Biomechanics And Mechanobiology
Dr. Yue Mei, Mines Saint-Etienne
Professor Stéphane Avril, Mines Saint-Etienne
Professor Jia Lu, University of Iowa
Summary: It has become a common practice to combine image based full-field displacement measurements experienced by tissue samples in vitro, with custom inverse methods to infer the best-fit material parameters and the rupture stresses and strains. Similar approaches have also applied to characterize the material parameters of soft tissues in vivo, where advanced medical imaging can provide precise measurements of tissue deformation under different modes of action, and inverse methodologies are used to derive material properties from measured data. Nowadays, these approaches offer important possibilities for fundamental mechanobiology which aims at gaining better insight in the growth, remodeling and aging effects in biological tissues. It is well-known that biological soft tissues appear to develop, grow, remodel, and adapt so as to maintain particular mechanical metrics (e.g., stress) near target values. To accomplish this, tissues often develop regionally varying stiffness, strength and anisotropy. Important challenges in soft tissue mechanics are now to develop and implement hybrid experimental - computational method to quantify regional variations in properties in situ.
The main motivation of the symposium is to review the latest progress and permit scientific discussions on these methods by bringing together researchers interested by characterizing material properties of soft tissues. Topics to be considered are related to the different challenges posed by inverse problems in soft tissue biomechanics and mechanobiology, such as:
- optimization approaches and model order reduction - model fitting against uncertain experimental results - uniqueness of identified parameters - reliability of computational models for biological tissues. - uncertainty assessment in inverse problems - optical full-field strain measurements - digital image/volume correlation - in vivo identification using medical imaging - virtual fields method - regularization approaches - inverse deformation problem - machine-learning and other data-driven approaches for parameter identification - hyperelastic image registration.
#5 Mini-symposium: The cross-talk between membrane and protein
Dr. Jiajie Diao, University of Cincinnati
Professor Baohua Ji, Zhejiang University
Summary: The mechanical properties of membranes enable a wealth of physical phenomena, many of which are also important for biological functions. Meanwhile, to induce impacts, proteins can change the membrane mechanics by altering membrane curvature and defects. These protein/membrane interactions are critical for many biological processes such as membrane fusion/fission. This symposium will cover recent developments on protein/membrane interaction research, including single molecule, cryo-EM, and molecular dynamics simulation. Speakers will have a wide spectrum of background ranging from theoretical to experimental
#6 Mini-symposium: Cellular and Molecular Mechanobiology
Dr. Yunfeng Chen, The Scripps Research Institute
Prof. David Bark, Colorado State University
Dr. David Martínez-Martín, ETH Zürich
Dr. Lining Arnold Ju, University of Sydney
Summary: In the last few years, we are thrilled to witness countless international collaborations in the field of biomechanics, which placed the proposed joint symposium at a most appropriate position to contribute to building a tightly-bonded biomechanics international community. This symposium will focus on cellular and molecular mechanobiology, a quickly thriving field contributed by many talented young scholars, as its major scientific topic. In this symposium, we will highlight the current challenges and most exciting breakthroughs in the study of cell adhesion, cell mechanosignaling, molecular binding and molecular mechanosensitivity in physiological functions like stem cell differentiation, immune responses, hemostasis, metastasis, and in related diseases. We will invite outstanding scientists (especially those who have established successful international collaborations) to present their latest discoveries and achievements. The goal is to build a platform for emerging leaders of the field to initiate new ideas and facilitate future personnel exchanges and collaborations on world-class projects.
Keywords: Cell adhesion; cell biomechanics and mechanosignaling; force-mediated molecular binding, dynamics and regulation
#7 Mini-symposium: Biomedical and Biotechnology Engineering
Dr. Lulu Wang, Hefei University of Technology
Dr. Liandong Yu, Hefei University of Technology Dr. Xiaoning Jiang, University of North Carolina
Dr. Sandra Costanzo, University of Calabria
Summary: This symposium focuses on the implementation of various engineering principles in the conception, design, development, analysis and operation of biomedical systems and applications. Authors and presenters are invited to participate in this symposium to expand international cooperation, to develop understanding of bio-engineering principles and methodology and to promote efforts in implementing engineering principles to biomedical systems. Dissemination of knowledge by presenting research results, new developments and novel concepts in developing these systems will serve as the foundation for this symposium program.
Topics will include but not be limited to: Injury and Damage Bio-mechanics Vibration and Acoustics in Biomedical Applications Biomedical Imaging, Therapy and Tissue Characterization Bio-materials and Tissue: Modelling, Synthesis, Fabrication and Characterization Biomedical Devices Dynamics and Control of Bio-mechanical Systems Clinical Applications of Bio-engineering Computational Modeling in Biomedical Applications Musculoskeletal and Sports Bio-mechanics Biosensors and Actuators
Keywords: Biomedical Imaging; Biomedical Devices; Biosensors and Actuators; Bio-mechanical Systems
#8 Mini-symposium: Multiscale Biomechanics and Mechanobiology in Basic Sciences and Physiological Applications
Dr. Mingxing Ouyang, Changzhou University
Dr. Peter Yingxiao Wang, University of California, San Diego
Dr. Kathy Shaoying Lu, University of California, San Diego
Dr. Jack Wei Chen, Zhejiang University
Summary: This symposium intends to introduce the fundamental-breaking or newest advancements in multiscale biomechanics and mechanobiology, ranging from nano to macro scales, and from molecular to body levels. This symposium also covers the emphasis of biomechanics on both basic sciences and physiology/pathology, reveals the novel developments in research methods and tools, and stimulates multidisciplinary interplays for biomechanical studies.
Keywords: Multiscale biomechanics, mechanobiology, biomechanics in physiology, multidisciplinary interplays in biomechanics, novel research tools
#9 Mini-symposium: Injury biomechanics and rehabilitation engineering
Yuan (Aaron) Feng, Shanghai Jiao Tong University
Lizhen Wang, Beihang University
Chih-Hsiu Cheng, Chang Gung University
Andrew Knutsen, The Henry M. Jackson Foundation for the Advancement of Military Medicine
Jiajia Luo, Shanghai Jiao Tong University
Tsung-Yuan Tsai, Shanghai Jiao Tong University
Haofei Liu, Tianjin University
Summary: This symposium will discuss human injury and rehabilitation related biomechanics and mechanobiology problems. A broad topic of injury and rehabilitation biomechanics involving various forms of injury, treatment and rehabilitation will be covered. Scientific discoveries as well as technical methods such as physical intervention, assistive technology, devices design, advanced manufacturing, 3D-Printing, computational simulation, imaging analysis, and mechanical testing will be discussed. Injuries and rehabilitation including but not limited to injury biomechanism, clinical treatment and rehabilitation methods of traumatic brain injury, sports related injury, hard tissue injury, soft tissue injury, etc.
#10 Mini-symposium: The "Virtual Biopsy" and Biomechanics: How Biomechanical Information Can Be Used to Image and Measure Tissue Properties In Vivo
Frederick Silver, Department of Pathology, RWJMS, Rutgers, the State University of New Jersey
Summary: Cancer cells and cancerous tissue have been shown to be characterized by altered stiffnesses in vitro using a number of different approaches. We have developed a technique to make virtual biopsies of tissues and elastic modulus measurements on normal skin and benign and malignant skin lesions. The technique involves use of optical coherence tomography and vibrational analysis to image and measure the resonant frequency of tissues based on the displacement of a tissue during transverse deformation in vivo. The image is made using near-infrared light and the transverse vibrations are achieved by applying a sinosoidal sound wave perpendicular to the tissue surface at a fixed wavelength. The resonant frequency is defined as the frequency of applied sound that causes the tissue displacement to be at a maximum. Our initial results suggest that the type and malignancy of a lesion can be defined by the cellular resonant frequency, the collagen modulus, the peak heights and widths.
Xiaobo Gong, Shanghai Jiao Tong University Ming Dao, Massachusetts Institute of Technology Ken-ichi Tsubota, Chiba University Chunyang Xiong, Peking University
Summary: This is a symposium for studying cellular scale fluid mechanics for biomedical purposes, which includes researches for the mechanisms of cell-fluid interactions with both simulations and experiments, and practical applications with microfluidics such as rare cell sorting, measurement of mechanical properties of cells, and design of chips for single cell analysis.